However, we found a cannabis tobacco interaction on diastolic BP, and independent effects of cannabis and tobacco on heart rate, which suggest that combining the two, increases the cardiovascular risk of smoking cannabis (for diastolic BP, the combined was lower than cannabis alone and tobacco alone, however this does not negate the increase in diastolic BP)
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Mary Ann McLaughlin, a cardiologist at Mount Sinai Hospital in New York City who reviewed the studies
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Hazen and a team of researchers found that a blood metabolite called 4PY which is formed by excess niacin and related compounds is associated with an increase in cardiovascular events like heart attack and stroke