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However, with federal regulation of e-cigarettes in place and an uncertain future as many remain under premarket review, some vape shops are now shifting to smoke shops (that sell both vape products and other tobacco products and accessories), diversifying their offerings to include a variety of tobacco products and (un- or under-regulated) cannabis-based products as well as kratom, as well as a growing their online retail segment, which can undermine federal, state and local restrictions on product sales in the retail environment, including youth access

At any age, cessation is beneficial to health, and the mortality rates of cigarette smokers who quit before age 35 are similar to those of people who never smoked

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PMID 37663224

A pilot study described in Additional File 1 was conducted to inform key parameters of the present two-stage adaptive randomised controlled trial (RCT)