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Smoking as well as hypertension, dyslipidemia, diabetes, obesity, aging, lack of exercise, excessive salt intake, and menopause are known to induce endothelial dysfunction [7]

[25] Early cultivation of tobacco [edit] In the first few years of tobacco cultivation in the colonies, the plants were simply covered with hay and left in the field to cure or "sweat." This method was abandoned after 1618, when regulations prohibited the use of valuable potential animal food for such purposes