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It is known to increase the risk of diseases such as heart diseases , diabetes , or even strokes

For some patients with rapidly, progressive or later stage disease, Lung transplantation can be a treatment option.See more: Tabla maestro Zakir Hussain passes away at 73: All you need to know about his life, family, career and legacyThe exact cause is unknown, but genetic predisposition, environmental exposures, and aging are potential risk factors

113, 114 The involvement of extracellular ATP and uric acid and the activation of the Nalp3inflammasome complex in the abrogation of inhalational tolerance and induction of aberrant Th2-driven inflammation by cigarette smoke represents an interesting working hypothesis for further investigation

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The second is abnormal relaxations of the LES, called transient LES relaxations