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71,72,73,76 One obstacle to preclinical use in animal models is the species specificity of the drug

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Interestingly, organs like the heart and brain may also benefit from stem cell treatments, as there are also other hormones and peptides in bone marrow like osteocalcin which have been shown to enhance memory, brain function, cardiac function, fitness, metabolism, healing, and tissue remodeling after ischemic damage [120-132, 151-161]

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[29] Omega-class GST (GSTO) genes, in particular, are associated with neurological diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis