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Lancet Respir Med 2020;8:54-64

Conventional cigarettes are designed to create and sustain addiction to nicotine

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Numerous studies to date have proved that the exposure to cigarette smoke increases the number of alveolar macrophages in the airway by several fold and induces changes in their morphology and phenotype [163,164]

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Participants were randomized in a 3:2 ratio to receive 12 weeks of 1 mg twice daily varenicline (n=300) or placebo (n=200) with 6 sessions of counseling and a culturally tailored educational guide