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This process promotes the translocation of Nrf2 to the nucleus, triggering the activation of antioxidant response elements and increasing the expression of genes involved in antioxidant defences and anti-inflammatory responses [131]

SJS/TEN is characterized by widespread skin and mucosal necrosis [5, 6]

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Additionally, changes in oxidative phosphorylation and the metabolic reprogramming of mitochondria in innate and adaptive immune cells were observed

Owing to their structural adaptability and generally favorable biocompatibility properties, largely dictated by the selected polymer matrix, these nanoscale systems have attracted considerable research interest (25)