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Larger devices with more e-liquid are ideal for heavy smokers, providing more puffs and extended use

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FDA control will in any case require amendments to FSPTCA-2009 38 , by analogy with the passage of increasingly flexible regulation of potent synthetic opiods 39

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However, only few studies addressed the role of SES when validating smoking intensity by cotinine concentration, and results differed by indicators of SES [10, 11]

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