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263,264 Furthermore, ALDH1A3-induced PKM2 tetramerization reprograms glycometabolism and increases lactate production in GSCs, leading to lactylation of XRCC1 at K247

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Similar context-dependent outcomes have been described in models of traumatic brain injury, where astrocytic reactivity initially limits tissue damage but later contributes to glial scar formation and synaptic dysfunction 38,39