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[16] Nicotine deregulates cardiac autonomic function, boosts sympathetic activation, raises heart rate, causes coronary and peripheral vasoconstriction, increases myocardial workload, and stimulates adrenal and neuronal catecholamine release

(107) suggests that the use of ENDS in 16-22-year-old participants is not associated with any neurocognitive impairments, once controlled for alcohol use, substance use, and sociodemographic factors

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