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Minor contributions to drug metabolism have been observed in vitro from CYP1A1, CYP2C8, and CYP2C18, though these enzymes are less relevant in vivo due to their lower hepatic expression compared to CYP3A4 (Shimada et al., 1994)

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They found that using an e-cigarette caused an instant increase in airway resistance that lasted for 10 minutes in the majority of the participants

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Estimates for smokeless tobacco use since 2015 are not comparable with estimates prior to 2015 because of questionnaire changes in 2015

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