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The endogenous acetylcholine input rate in your brain also plays a crucial role in determining how strongly dopamine neurons respond to nicotine

The toxic dose is as low as 1-9.2mg/kg of the pets body weight, which means that just a quarter teaspoon of nicotine-containing e-juice can poison a dog weighing 18kg

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Over time, tolerance develops, requiring higher doses to achieve the same effect

Increased Risk of Infections: The immune system in the respiratory tract is compromised by smoking, making individuals more susceptible to infections such as pneumonia and bronchitis