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Since the most intercalating compound corresponded with the most potent topoisomerase I poison and cytotoxic agent, the 9-methyl ( 2 ) and 9-phenylpropyl ( 3 ) derivatives of harmine displayed a significant and broader spectrum of cytotoxic activities against the three tumor cell lines examined (human lung carcinoma 95-D, gastric carcinoma SGC7901 and hepatocellular carcinoma HepG2)

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The color difference was then analyzed by two-way ANOVA using SPSSAU with two sets of additional E * values (Supplementary Table S1), and the results were presented in Table 2