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2,3-Butanedione has been linked to a rare but severe lung disease called bronchiolitis obliterans, which is also known as popcorn lung, a term adapted when popcorn factory workers acquired the disease after being exposed to high levels of the vaporized substance

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Treatment plans should be tailored to individual patients, taking into account each patients needs and preferences

These results suggest that smoking may worsen the severity of the disease and prolong the disease course and drug treatment with immunosuppressants

Reynolds, the second-largest tobacco company in the United States