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A prospective therapeutic drug monitoring study showed that steady-state plasma olanzapine concentration/dose ratio closely correlated with CYP1A2 metabolic activity, and described a statistically significant five-fold lower dose-corrected steady-state plasma olanzapine concentration in smokers [21]

Because of this the rest of the chemicals in the cigarette are absorbed faster by the lungs so you get that nicotine hit faster and harder then you normally would

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