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After 16 weeks, all animals were challenged by intratracheal instillation of nontypeable Haemophilus influenzae (NTHI), an opportunistic gram-negative bacterium responsible for respiratory tract infections and exacerbations in COPD patients [23], and euthanized 0, 4, and 12 h later

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It may impart upon its user a "buzz" somewhat more intense than that of tobacco chewing, snuffing and smoking