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doi: 10.1001/jama.292.7.807 18 WhittingtonCJKendallTFonagyPCottrellDCotgroveABoddingtonE

A recent study from the Cochrane Library found 'high-certainty' evidence that E-Cigarettes are more effective for quitting smoking than traditional forms of nicotine replacement therapy, like nicotine patches and nicotine gum

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Klosterhalfen, S., Viechtbauer, W

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While the pills may have contained a sedative that helped with sleep, it is also possible the Shakers went out on a rather dangerous limb and offered a cure that contained Datura Stramonium more commonly known at that time as Thorn Apple