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Nonetheless, neuroimaging studies have documented smoking-related volumetric increases in the caudate and putamen [17, 86], positive correlations between putamen volume and lifetime nicotine/tobacco exposure [107], and positive correlations between greater striatal volume and more intense cue-induced tobacco craving [108]

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There's a review of reviews, which we call as a systematic review from Cochran Foundation that also showed that as compared to the best sort of treatment currently, whether it's clean, whether it's NRTs, nicotine, vapes, double the rate of sort of quitting cigarettes

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