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Image courtesy of Phillips de Pury Sally Mann, Candy Cigarette (1989), sold for $266,500 at Phillips de Pury in New York on April 4, 2012

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3 Nicotine pharmacology and cardiovascular effects 3.1 Mechanisms of nicotine action As detailed by Benowitz (22) in his comprehensive review of nicotine pharmacology, nicotines addictive potential stems from its complex interaction with the nervous system, involving rapid central nervous system penetration and subsequent activation of neural reward pathways

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