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Patience is key

High barriers to entry select only large tobacco companies that can cross-subsidize compliance costs from their cigarette sales or those with high-volume products and a revenue stream justifying high regulatory costs

Risk of Coronary Heart Disease Among Smokeless Tobacco Users: Results of Systematic Review and Meta-Analysis of Global Data

The earliest pipes were made of stone, and tended towards tubular or platform types, while late prehistory was dominated by numerous plain clay pipes with occasionally more elaborate, often effigy, specimens as well

10.1086/430323 117 WangH.LiaoH.OchaniM.JustinianiM.LinX.YangL.et al (2004)

The history of regulating basic human appetites for sex, power, money and drugs, is not edifying