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Findings are less likely to be generalizable to the US adult population of smokers or e-cigarette users, adult smokers who use other brands of e-cigarette, adult smokers who use a JUUL vaporizer for reasons other than to support an attempt to quit smoking, and adult smokers who are less motivated to use e-cigarettes, such as those randomized to receive e-cigarettes or other alternative nicotine products as part of a clinical trial

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