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22 From the blood, nicotine quickly diffuses into breast milk

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but in cases such as that under consideration, in which the paroxysms returned early in the morning, and subsided in a few hours, the difficulty of obtaining the means of smoking it was one objection to its employment

Fumigation ( dhupa ) and fire offerings ( homa ) are prescribed in the Ayurveda for medical purposes and have been practiced for at least 3,000 years while smoking, dhumrapana (literally "drinking smoke"), has been practiced for at least 2,000 years

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