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they are at particularly high risk if they use both tobacco and alcohol.[2] Individuals who chew betel quid (whether mixed with tobacco or not) are also at high risk of cancer of the oral cavity and oropharynx.[3,4] Individuals who have a personal history of cancer of the head and neck region also are at elevated risk of a future primary cancer of the head and neck.[5] Human papillomavirus type 16 (HPV-16) is a sufficient, but not necessary, cause of oral, tongue, and oropharyngeal cancers.[2,6] Note: Separate PDQ summaries on Oral Cavity and Nasopharyngeal Cancers Screening and Cigarette Smoking: Health Risks and How to Quit are also available

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Its use in commercial advertising by 1975 reflects the full absorption of Op Art principles into mainstream design practice, and it was executed here with real sophistication