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Nicotine delivery however was statistically significantly different, again in terms of C max and AUC, than nicotine delivery from subjects usual brand of cigarettes

While the argument around this is that plain packaging is the ultimate form an encumbrance, in its complete suppression, and the Article, mentioning a non-exhaustive list, could perhaps include plain packaging as an encumbrance under it

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British Journal of Oral and Maxillofacial Surgery

For most healthy adults, these effects are short-lived

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