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also observed that smoke-conditioned media significantly suppressed the activation of NFB and IRF-3 in nonsmokers' PBMCs treated with poly I:C [147], while cigarette smoke extract was shown to dramatically elevate the DNA binding activity of AP-1 rather than NFB in endothelial cells of human umbilical core vein [148]

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[15] In 1991 Norton again commercially declined and John Player withdrew sponsorship for a second time

In 1993, the program was revived by the National Health Protection Institute with the support of pharmaceutical companies