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Table 1 Methodological quality assessment of the studies included in the systematic review Table 2 Description of the studies selected about EC use risk and protective factors, and motives for use In Figure 2, most studies are cross-sectional 47,50-53,55-58,64,66,67,70,71,75,78,79,96 , followed by longitudinal studies 54,61,62,68,74,76,77,80

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While some provinces are known for cheaper tobacco products, others have implemented higher taxes that make smoking significantly more expensive

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The list of research needs to inform FDA and ENDS regulation will be prioritized with respect to: --research to gather information of most importance for the regulation of ENDS to protect the population health