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What happens when nicotine leaves the body

2007 Dec 12;73(1)

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One of the most compelling concerns about teenagers and e-cigarettes, however, is related to nicotine, a highly addictive chemical that has also been shown to negatively affect brain development, particularly the cerebral cortex and hippocampus, the parts of the brain that are responsible for decision-making and impulse control

The decrease in the average litter size produced by the untreated female rats used in mating the treated male rats might be due to the effects of nicotine on the progressive epididymal sperm motility