cigarette smoking and atherosclerosis can cause atherosclerosis. Smoking can cause endothelial cell Frontiers | A modern day

By comparison, 16% said theyd tried cigarettes at some point, up from 13% two years prior

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This catalyst effect, supported by findings that initial E-cigarette use predicts future smoking and that product initiation correlates with increased susceptibility to other products, means that pouch use might not only establish nicotine dependence but could also serve as a gateway to initiating or maintaining the use of other, potentially more harmful, products like cigarettes or E-cigarettes (30, 31)

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