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Cyanocobalamin formulations contain trace amounts of cyanide and are contraindicated in patients with Leber's hereditary optic neuropathy

This direct approach ensures that the vitamin is absorbed efficiently, especially in individuals who may have difficulty absorbing B12 through the digestive tract due to certain health conditions

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The treatment also decreased pro-inflammatory and pro-fibrotic gene expression with reduced macrophage infiltration (Li et al., 2025)

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