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1 Introduction Tobacco, as one of the globally significant cash crops, generates substantial biomass residues during cultivation and processing ( Tobacco leaves are known to contain over 4,000 structurally diverse phytochemicals exhibiting significant bioactivity at minimal dosages (Figure 1a) functions as a key aroma-transport mediator, facilitating the transfer of volatile flavor compounds into combustion aerosols ( FIGURE 1 While tobacco provides significant economic benefits, it also poses serious health risks to the public (Supplementary Figure S1)