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Not always

Todd, at the University of Cambridge, used the LLD assay to extract the anti-pernicious anemia factor from liver extracts, purify it, and name it vitamin B 12

Rather than focusing solely on observable tissue changes, these investigations often seek to understand the molecular events that occur before structural adaptations become visible

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However, elevated levels may indicate underlying conditions such as liver disease, haematological disorders, or kidney impairment that require medical investigation and management

doi: 10.1002/jps.2600820619