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This physiological mechanism, which is useful for the post-translational modification of multiple proteins and for the regulation of signal and metabolic pathways, can turn harmful in case of oxidative stress, with the above-mentioned mitochondrial damage

(2016, Indian Journal of Dermatology, Venereology and Leprology ) the most comprehensive published review on this topic concluded that the evidence for intravenous glutathione as a skin-lightening agent remains limited and of low quality