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In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )

183, 409417 10.1083/jcb.200806024 [DOI] [PMC free article] [PubMed] [Google Scholar] Mllgrd K., Balslev Y., Lauritzen B., Saunders N

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doi: 10.1038/s41598-021-93546-5 9 BeyerstedtS.EBC.RangelB

What The Human And Animal Data Actually Shows Quick summary across all forms (the modifications didnt exist as separate test compounds in most of these most of the older literature is on base epithalon or epithalamin): Khavinson, Bondarev, Butyugov (2003)

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