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According to the FDA, more than 3 million middle school and high school students use e-cigarettes

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A Historical Association: Tobacco and Cancer The relationship between tobacco and cancer is one of the most well-documentedand hard-wonpublic health discoveries of the 20th century

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This analysis of drug harms in Canada found that alcohol causes the most harm overall Alcohol was followed by tobacco, nonprescription opioids (like fentanyl), cocaine, methamphetamine, and cannabis. Tobacco ranked first in 4 of the 16 harm categories: drug-related mortality, drug-specific damage to physical health, dependence, and environmental damage, the researchers wrote