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20 minutes before beginning testing 3 month old male Sprague Dawley rats were given scopolamine directly into the brain (icv) and 15 minutes later dihexa was given either icv, intraperitoneal ly (ip), or orally

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It is thought that the secondary pathway by which AOD9604 causes fat loss, the pathway that is independent of beta-3-adrenergic receptor activation, may play a role in improving metabolic metrics even while it boosts fat loss- AOD9604 exhibits minimal side effects, high oral and excellent subcutaneous bioavailability in mice