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Moving forward, it will be essential to optimize the exposure conditions to support a chronic smoke regimen, including adjustments to higher dilution flow rates and longer exposure duration, to enable a more controlled and physiologically relevant modeling of chronic smoke-induced effects

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Notably, in vitro studies report that clofazimine also inhibits CYP2C8, CYP2D6, and CYP3A4/5, indicating the likelihood of clinically significant interactions with drugs metabolised by these isoenzymes (Lamprene, 2019

The smoke that burns off the end of your lit cigarette contains more harmful substances nicotine, tar, carbon monoxide and more nasty stuff than the smoke that youre actually inhaling

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