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Many of JUULs marketing approachesincluding TV adsare illegal for conventional cigarettes precisely because such tactics promote youth initiation and progression to ongoing use

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Together, these trees form a genome-wide genealogical record that underpins downstream analyses, providing the framework for estimating coalescence times, detecting selective sweeps and accounting for genetic relatedness in the genome-wide association study (GWAS) 38

The tobacco industry has long appealed to youth through targeted marketing that glamorizes smoking with imagery of candy-flavored products, celebrity endorsements, social settings, and other enticing tactics