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Concurrently, nicotine in combustible tobacco can also induce OS and vascular endothelial damage, thereby contributing to the development of hypertension 31

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Hyperglycemia, particularly in combination with hyperinsulinemia, leads to a procoagulant state by increased levels of TF, decreased factor VII/VIIa and increased factor VIII and prothrombin fragment F1.2 [70]

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