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Am J Respir Cell Mol Biol 6:287295 Di Stefano A, Maestrelli P, Roggeri A, Turato G, Calabro S, Potena A, Mapp CE, Ciaccia A, Covacev L, Fabbri LM, Saetta M (1994) Upregulation of adhesion molecules in the bronchial mucosa of subjects with chronic obstructive bronchitis

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Maybe this will help us to understand that in people who have smoked for a long time, you need to make a different approach because their adaptive immune response is going to be poor. Thanavala cautions, however, that the cytokine profiles in smokers or former smokers do not translate directly to a worse adaptive immune response to real-world infections or toxin exposures