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| CrossRef | PubMed | Fernandez R, Griffiths R, Everett B, Davidson P, Salamonson Y, Andrew S

Our study indicates that chemical constituents of e-cigarettes could contribute to cardiac risk by provoking pro-arrhythmic changes and stimulating autonomic reflexes

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We assessed strength of association by calculating odds ratios (OR)

Taken together, our study showed that nicotine induced mitochondrial dynamics disorder by blocking mitophagic flux by repressing CTSL activity and activating ROS-mediated p38/JNK pathways, while Torin1 rescued NRVMs by restoring CTSL activity and damaged mitophagic flux