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These data suggest that adding in a behavioral substitute, like a VLNC, might be another helpful tool to tackling tobacco addiction. The Options study was made possible by a $1.4 million three-year grant from the National Cancer Institute and Food and Drug Administration to the University of Wisconsin Center for Tobacco Research and Intervention

Tobacco use sharply raises levels of oxidant stress and inflammation, increasing the risk for a plethora of diseases and serious conditions

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Those on placebo survived a median of 5.6 months without the disease progressing, compared to 39 months on the drug nearly three extra years