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"Together they show that the epidemic of disease and death caused by cigarette smoking increases progressively over many decades, peaking 50 or more years after the widespread uptake of smoking in adolescence

regulators published a mixed review Monday of the closely watched cigarette alternative from Philip Morris International

The number of puffs may vary based on factors like puff duration and frequency of use

While e-cigarettes don't contain many of the cancer-causing byproducts of cigarette smoke, there isn't much long-term evidence of vaping's health effects

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