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Critics worry the slick packaging and marketing around IQOS seems more geared toward grabbing the attention of youth than helping wean longtime smokers off cigarettes

These cigarette filters are often made of very tightly pressed cellulose acetate

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had access to specialized smoking machines, which enabled realistic smoking regimes (e.g., a 1.8 second puff with 10 second intervals between puffs)

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For the majority of algorithms, sensitivities and/or specificities differed significantly according to principal diagnosis, number of comorbidities, socioeconomic status, residential remoteness, Indigenous status, 28 day readmission and 365 day mortality