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Vaisman N, Hahn T (1991)

Reynolds Tobacco Co., said he hopes to work with the FDA to establish a regulatory framework that is based on tobacco harm reduction and recognizes the continuum of risk. The proposal harks back to 1976, when tobacco researcher Michael Russell observed that people smoke for the nicotine

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Regular use can lead to a nicotine use disorder and is associated with other substance use problems, as well as mood disorders in adulthood