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Withdrawal symptoms: When attempting to stop or reduce Adderall use, individuals experience withdrawal symptoms such as fatigue, depression, irritability, and intense cravings

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Compared to those reporting no fatigue, moderately fatigued participants had 64% higher odds of relapse (odds ratio = 1.64, 95% confidence interval = 1.212.23), while highly fatigued participants had 81% higher odds (odds ratio = 1.81, 95% CI = 1.073.07)