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Although Diazepam Rectal Gel is indicated only for intermittent use (see INDICATIONS AND USAGE and DOSAGE AND ADMINISTRATION), if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction or administration of flumazenil, a benzodiazepine antagonist, may precipitate acute withdrawal reactions, including seizures, which can be life-threatening

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Data collection All subjects aged 20 years or older were recruited by the MJ Health Group, Taiwan, to participate in a standard health-screening program between 1994 and 2008