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The larger size of the positive study might be more adequately powered to find an effect for gabapentin

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To make sure policy decisions around e-cigarettes continue to be evidence-based, and allow the devices to reach their potential to help smokers quit, we need more research

Farber HJ, Groner J, Walley S, Nelson K, Section on Tobacco Control

And according to the American Association of Kidney Patients (AAKP), studies have shown that smoking is harmful for the kidneys, and can cause kidney disease to progress and increases the risk for proteinuria (excessive amount of protein in the urine)