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To reduce the effect of bias, we adjusted observations that did not account for more than five confounders, including age and sex, because they were the significant bias covariates identified by the bias covariate selection algorithm 29 (Supplementary Table 7)

A pack of 100s is 3.9"x2.17"x.79". Measuring the inside dimension of the holder, it should accommodate a pack of 100s. Some packs, in particular hard packs, may be a bit larger depending on the brand

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