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Further research, including pharmacokinetic studies in smokers versus nonsmokers, is warranted to clarify the impact of smoking on ifosfamide and cyclophosphamide levels, and nicotines impact on cancer cell biology and chemosensitivity

(4) presence of sensitivity/supplementary analyses, and robustness of findings across different analyses

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In addition, higher-generation devices such as mods were associated with the strongest and most consistent changes in gene regulation

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