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As a second hypothesis, the considerable impact of cigarette smoke on the ileal mucosa can be attributed to the fact that this area suffers from a high exposure to these cigarette compounds (Figure 1)

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This legislation (known as Tobacco 21 or T21) makes it illegal for a retailer to sell tobacco productsincluding cigarettes, cigars, and e-cigarettesto anyone under the age of 21

A small number of subjects also had a slight increase in slow wave sleep, the deepest stage of sleep

It is a symptom rather than a disease itself and can be associated with a wide range of lifestyle and medical factors